Apoquel vs Benadryl For Dogs. Which is Better?

Allergy season is upon us. Through your watery eyes and in between sneezes, you may have noticed that your dog isn’t having the greatest time either. Dogs can suffer from allergies as well, which can be challenging to treat.

With many products out there to help control allergies in dogs, which one is best? Let’s compare two commonly used products: Apoquel and Benadryl.

Simply put, an allergy is an overreaction of your immune system to something called an allergen. Allergens can come from plants, animals, insects, or food.

How To Tell If Your Dog Has Allergies

It’s the immune reaction that we see as symptoms of an allergy. Those include: – Itching all over or in specific areas – Rash – Coughing, sneezing, wheezing – Watery eyes, runny nose – Vomiting, diarrhea

Apoquel is an immune suppressant drug that helps to block the inflammatory reaction, specifically for the sensation of itchy. It is more specific than steroids so that you don’t see as many side effects.


Benadryl is an antihistamine that also works as a mild sedative to help ease anxiety. It works well for mild allergic reactions, such as an insect bite or sting. It can also be used for more long-term allergies but has varying results.


Which medication is best for your dog depends on what you’re after. If your puppy has mild itchiness that comes and goes, Benadryl may be your best bet. If your dog has more long-term allergies that plague them seasonally or even year-round, Apoquel is probably a better choice.

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